A vaccine against HTLV-1 HBZ makes sense.
نویسنده
چکیده
In this issue of Blood, Sugata et al report that vaccination against human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper (bZIP) factor (HBZ) could be used for immunotherapy in adult T-cell leukemia-lymphoma (ATL) patients.
منابع مشابه
HTLV-1 bZIP factor gene: Its roles in HTLV-1 pathogenesis.
The HTLV-1 bZIP factor (HBZ) gene is transcribed as an anti-sense transcript of HTLV-1 from the 3' long terminal repeat (LTR). Recent studies showed that the HBZ gene was expressed in all ATL cases, suggesting its critical role in leukemogenesis. In addition, only the HBZ gene sequence remains intact, unaffected by nonsense mutations and deletion. HBZ mRNA promotes proliferation of adult T-cell...
متن کاملEffects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes.
A determinant of human T-lymphotropic virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development is the HTLV-1-infected cell burden. Viral proteins Tax and HBZ, encoded by the sense and antisense strands of the pX region, respectively, play key roles in HTLV-1 persistence. Tax drives CD4(+)-T cell clonal expansion and is the immunodominant viral antigen recognized...
متن کاملProtective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases in a small percentage of infected individuals. Host immune responses, in particular cytotoxic T lymphocytes (CTLs), influence the proliferation and survival of ATL cells and HTLV-1-infected cells. We generated recombinant vaccinia viruses (rVVs) expressing HTLV-1 basic leucine zippe...
متن کاملMaking Sense out of Antisense Transcription in Human T-Cell Lymphotropic Viruses (HTLVs)
Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' long terminal repeat (LTR), which is either unspliced or alternatively spliced. We and others have demonstrated the existence of an antisense transcript initiating in the 3' LTR of the Human T-cell Leukemia Virus type 1 (HTLV-1) that is involved in the production of HBZ (HTLV-1 basic leucine zipper...
متن کاملFunctional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.
UNLABELLED Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T cells in vitro but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits Tax-1-mediated viral transcription and promotes cell proliferation, a hig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Blood
دوره 126 9 شماره
صفحات -
تاریخ انتشار 2015